Back to the circle crank experiment........
When you begin porting for the reduced case volume, remember that it will be hard to grind more volume of material out of the transfers, than what was added by the cranks filler material. This gives you an excellent opportunity to enlarge and shape the tunnels to a much greater extent than normal, even if you have to add epoxy to the outside.
A good example of this is the 576xp, 562xp, and maybe some others. They have full circle cranks, and very long, well-aimed transfers taking advantage of the reduced case volume.