The only difference is the main jet size as pointed out above.
The HD50 461 carb is supposed to have a better intermediate circuit-I personally haven’t noticed a difference.
I’d get a set of micro drills and drill out the jet you have slowly. It threads right out and is quite simple to do. You don’t even have to fully remove the carb, just slide it back and pull the metering cover.
FWIW, see where the H screw is at now tuned correctly. If it’s under 50*F, you are less than 1000’ above sea level and you are under 1.5 turns out, I’d leave it alone. Once it gets hot out and/or you go to a higher elevation, you will need to lean the H out. Too big a jet and that won’t happen. These carbs feed the main nozzle via a fixed and adjustable circuit. The jet feeds the fixed circuit and if you go too big, the adjustable circuit will stop working.